The confirmed cases of corona infected patients are rising rapidly across the globe. More cases of Coronavirus disease are being expected across many regions of the world. Though, constant efforts at the individual, national, and international levels are being made to fight back against this pandemic. thus, the growth in the number of patients leads to high demand for rapid antigen test kits in the market. Rapid Diagnostic Tests (RDTs) are small, simple to use, stand-alone tests. They can be used by minimally trained staff, round the clock, and on single samples at the point of treatment, thus benefitting the whole market.
·Studies indicate that most patients produce an antibody response only after symptom onset during the second week. This means that COVID-19 infection diagnosis based on antibody response will often only be possible in the recovery phase when many of the opportunities for therapeutic intervention or disease transmission disruption have already passed. Antibody detection studies targeting COVID-19 can also cross-react with other pathogens, including other human coronaviruses, and result in false positives. Finally, whether RDTs detecting antibodies could predict whether an individual was resistant to COVID-19 virus reinfection, was examined.
Blood samples were obtained from COVID-19 patients from various hospitals and from Chinese CDC laboratories to test the detection sensitivity and specificity of the combined antibody test COVID-19 IgG-IgM. At each site, the experiments were carried out separately. A total of 525 cases were tested: 397 (positive) clinically confirmed (including the PCR test) patients infected with SARS-CoV-2 and 128 patients who were not infected with SARS-CoV-2 (128 negatives).
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